Intralipid therapy will not be prescribed for you if you have a history of liver failure, kidney disease, hyperlipidemia, or a sensitivity (allergy) to soy, eggs, or peanuts. Some patients may experience chills, malaise, headaches, nausea, vomiting, chest pain, shortness of breath, or an allergic type reaction. The risks associated with an Intralipid infusion are low. Intralipid has been used safely for over 30 years. What are the Risks of Intralipid infusions? The first infusion is administered around ovulation (or at time of IUI), the second infusion after a positive pregnancy test, the third infusion after a viable pregnancy has been confirmed by ultrasound scan at six or seven weeks of gestation the last infusion is given four or five weeks later.Īfter that the embryo should be established enough to develop without further Intralipid support. Usual 3-4 infusions are given to establish a healthy pregnancy. Intralipid is administered by intravenous drip infusion over a period of 2 – 3 hours. Studies have shown that Intralipid can help to regulate the NK cells, allowing the embryo to implant on the uterine wall and grow normally. Intralipid therapy has been shown to lower the activity of the natural killer cells of our immune system. This would make it difficult or impossible for the embryo to implant in the lining of the uterus. However, when these ‘friendly’ cells are not present or effective, the mother’s immune system may attack or reject the embryo with so-called ‘natural killer’ (NK) cells. Normally, the lining of the uterus contains immune cells that are specially adapted to tolerate an embryo. Research has shown that Intralipid enhances successful implantation and maintenance of pregnancies in patients with auto-immune disease, recurrent miscarriages and/ or unsuccessful IVF attempts. Allergies (seasonal & food sensitivities).Prenatal, Pregnancy and Post-natal Care.Compatibility of medications with intravenous lipid emulsions: Effects of simulated Y-site mixing. Ross EL, Salinas A, Petty K, Her C, Carpenter JF. Data regarding Y-site compatibility for one lipid emulsion product cannot be safely extrapolated to another without additional testing. The two combinations that met USP criteria for physical incompatibility were cisatracurium 2 mg/mL with Intralipid and gentamicin 2 mg/mL with Smoflipid.Ĭonclusion: Three different lipid emulsions were physically compatible at the Y site with the majority of medications tested. Incompatibilities differed for the different brands of lipid emulsion. Results: Most combinations tested were physically compatible based on USP regulations. Physical compatibility was determined by measuring the percentage of fat residing in globules larger than 5 µm (PFAT5) per USP recommendations. In patients without central access, calcium gluconate is preferred. Each sample was then diluted with particle-free water and analyzed using the analytical technique of light obscuration recommended in United States Pharmacopeia (USP) general information chapter 729 (USP ). IV calcium should be administered as slow pushes over at least 5 minutes, to minimize side effects. Methods: Medications at commonly used pediatric concentrations were mixed in a 1:1 ratio with lipid emulsions (Intralipid, Nutrilipid, and Smoflipid) and incubated at room temperature for 4 hours to simulate Y-site administration. Intralipid or lipid emulsion, is an intravenous infusion. Purpose: To determine the physical intravenous Y-site compatibility of 19 commonly used medications at pediatric concentrations with 3 different types of lipid emulsion. Intralipid is used for improving implantation in patients with high natural killer cell activity.
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